Hi FreddyS,
For your first question, you can jump from profile to profile but not automatically. Unfortunately, our software doesn't support any macros to automate this process. Pins PS0-2 are controlled by a microcontroller which in return controlled by the GUI. You can use evaluation software's debug mode to manually control the profile pins. Another way is to get the source code of the GUI and change the software itself, but I don't think it's practical.
Value 0101b in the function pins changes the operating mode of the DDS to direct amplitude and phase control. This gives you the ability to change the phase and amplitude of the signal simultaneously. Kindly refer to page 28 of the data sheet to know more about this.
Best Regards
Loujiie